The Biphasic Properties of CBD
Research has shown that cannabidiol has a myriad of effects on the human body. Because of its numerous positive effects, CBD Cannabidiol can be used to treat many different conditions safely. However, when a patient consumes CBD, following proper dosing instructions is extremely important. Cannabidiol is has biphasic properties and may not produce the desired effect if the dose consumed is too high or too low.
A biphasic drug is one that has differing effects on the body at different blood concentration levels. One of the most well known biphasic drugs is alcohol, which acts as a stimulant until blood alcohol levels reach 0.05 percent. After this point, continued consumption of alcohol causes sedation and depression.
Cannabidiol’s Biphasic Response
According to John Hicks, MD, cannabidiol’s initial effect is stimulating. When CBD interacts with the endocannabinoid system at lower levels, it has been shown to increase wakefulness, alertness and other such traits among patients. Low doses of CBD can also contribute to elevated mood. At higher doses, however, CBD has a sedating effect instead. For example, people who consume larger amounts of CBD may feel sleepy and calm, as opposed to alert and energetic.
Implications in Treatment
Because of cannabidiol’s biphasic properties, it can be used to treat a large variety of problems on both ends of the spectrum, from insomnia to depression. However, in order to effectively treat a specific problem, the proper dose of CBD must be consumed. For example, research published by cannabisclinicians.org reports that patients who received only 15 mg of cannabidiol reported feeling more clear-minded and alert. Studies also showed that patients receiving a 15 mg dose of cannabidiol experienced more wakefulness during sleep than those who did not take CBD. Patients receiving 600 mg doses of cannabidiol, on the other hand, reported feeling more sedated. Furthermore, even at a dose of 160 mg, studies show that cannabidiol increases sleep duration.
Advice for Patients
When taking cannabidiol, it is extremely important to take the recommended dose at regular intervals. Raising or lowering your dosage may produce the opposite of the desired effect, and taking your medication at the wrong times may lead to unintended increases or decreases in blood concentrations of CBD.
Keep in mind that some people may metabolize cannabidiol differently because of anomalies within the cytochrome P-45O enzyme system. This system, which is responsible for metabolizing cannabidiol, may behave differently than it should because of liver problems, genetics or an interaction with other drugs taken concurrently. If you suspect that you are not metabolizing CBD as expected, ask your doctor to test your cytochrome P-450 enzyme system before adjusting your dosage.
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