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CBD Oil Dosage: General Tips to Assess How Much CBD to Take

By and large, the acceptance and use of cannabidiol as a therapeutic, healing substance is in its infancy. Medical professionals and scientists are only now beginning to develop dosing schedules for medical marijuana, medicinal hemp, and their extracts (including CBD).

Even with the current wave of states legalizing medical marijuana, many physicians are hesitant to prescribe cannabinoids like CBD. This is for two reasons:

1 – Doctors cannot prescribe (only recommend) cannabinoids, because there’s no recommended daily allowance (RDA) or universal dose for all people.

2 – Most medical schools never cover CBD/cannabidiol therapy in their pharmacology courses (the drug curriculum revolves primarily around substances that can be patented).

Because there is no recommended dose, the information presented on this page is intended to serve only as an informational guide – a starting point of reference – and should never be considered medical advice.

When it comes to cannabinoids, there is one universal truth to keep in mind:

Everyone Is Different

There are countless variables such as weight, diet, metabolism, genetics, environment, product consistency, and more that make a universally prescribed dosage an impossibility.

While we wish we could provide the public with a mathematical CBD dosage calculator, it isn’t quite that simple – very rough estimates are about as good as it gets.

With these facts in mind, most people who are new to cannabidiol begin their journey by starting with the minimal suggested CBD dosage on any product, then gradually increasing the dose until they achieve the desired results.

We at CBD Oil Review (COR) have created an official COR Serving Standard through an extensive analysis of hundreds of CBD products.

The (COR) Serving Standard is 25mg of CBD, taken twice daily.

Additionally, our analysis suggests  increasing the amount of CBD you take every 3-4 weeks by 25mg until you attain symptom relief (inversely, decrease by 25mg if symptoms worsen).

Additionally, you might find it useful to record your daily experiences in a notebook so you can accurately narrow in on what works and feels best for you. With that understanding in place, it is now time to learn more about CBD oil and how to find the right CBD oil dosage for you.

How Much CBD Oil Should I Take?

Mayo Clinic suggests CBD dosages based on scientific research, publications, traditional use, and expert opinion. Cannabinoid dosages and duration of treatment depend mainly on the illness (and countless other factors).

The Mayo Clinic provides specific dosage recommendations for various illnesses, including:

  • Loss of Appetite in Cancer Patients: 2.5mg of THC (orally), with or without 1mg of CBD for six weeks. [S
  • Pain Relief: 100-150mg of CBD, or 25mg when combined with THC.[S, S, S]
  • Epilepsy: A daily dose of 20 – 25mg of CBD per Kg bodyweight. [S, S]
  • Movement Problems Due to Huntington’s Disease: 10mg of CBD per kg of body weight daily for six weeks (orally). [S]
  • Sleep Disorders: 40mg-160mg of CBD (orally). [S]
  • Multiple Sclerosis (MS) symptoms: Cannabis plant extracts containing 2.5-120 milligrams of a THC/CBD combination daily for 2-15 weeks. Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24-hour period. [S]
  • Schizophrenia: 40-1,280mg oral CBD daily. [S]

Learn the Types of CBD Products

CBD hemp oil comes in seemingly endless forms, each with a different concentration of CBD and other phytocannabinoids. Determining how to use CBD oil first starts with choosing your route of administration – in other words, choosing the best way to take CBD oil for your needs and lifestyle.  

These include…

Ingestibles:

  • Liquid hemp oil, like CBD tinctures or CBD drops
  • CBD concentrated into a thick paste (often referred to as Rick Simpson Oil, or RSO)
  • Encapsulated CBD oil
  • Phytocannabinoid-rich sprays/spritzers (generally designed for application beneath the tongue)
  • Bottled water containing nano-sized CBD particles
  • CBD-infused chewing gum
  • On-the-go dissolvable powders containing CBD (oftentimes blended with other adaptogenic herbs)
  • Cooking oils (such as coconut oil or olive oil) with added cannabinoids
  • CBD-infused edibles (i.e., gummies, brownies, cookies, etc.; generally for individuals who are sensitive to smoking/vaping)

Smokables:

  • Crystalline isolates
  • Wax (similar to THC-containing marijuana concentrates called “shatter”)
  • CBD-rich eLiquids and/or vape cartridges (akin to an e-cigarette)

Topicals:

  • Transdermal patches with CBD (similar to a nicotine patch)
  • Cannabidiol-infused salves,balms, lotions, shampoos, or soaps (for topical use)
  • Bath bombs infused with CBD

Decide How to Use CBD Oil

While many options like chewing gum need no instructions, we have compiled these tips on how to take CBD oil:

Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.

CBD E-Liquid/Vape Cartridges: Vaping is excellent for people looking for an immediate response, as inhalation is the fastest way to deliver CBDs to your brain and body. To use vape simply exhale gently the air from your lungs then inhale through the mouthpiece slowly for 3 seconds. Then fill your lungs the rest of the way with additional breath and hold for a few seconds, exhaling when ready. There are pre-filled, cost-effective vape pens and cartridges available as well as more expensive vaporizers that you can refill with CBD-infused e-liquid.

CBD Edibles: With edibles, the only required steps are open, eat, and enjoy! This method of consumption will result in more drawn-out effects that also take longer to kick in than some of the other options. Edibles are great for those seeking sustained effects, or for those who want to be subtle about their usage of CBDs.

CBD Isolates/Concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this delivery method. Simply sprinkle some into a vaporizer or water pipe, ignite, inhale, and enjoy! We find that this option is useful for individuals looking to elevate their regular consumption of CBD-rich cannabis flowers or other smokable herbs.

For quick reference, refer to this chart of ingestion methods for the pros and cons of each delivery method so can decide for yourself the best way to take CBD oil:

Delivery Method Pros Cons Time of Onset Duration of Effects Recommended if you…
Ingestibles (E.g. edibles; capsules; oil drops; drink powders) Convenient; Dosage control; Discreet; Familiar; Doesn't harm the lungs Slow to take effect 30-60 minutes Edibles/Capsules:4-6 hours; Tinctures/Drops: 2-4 hours Consider discretion a top priority and/or want more control over dosage
Smokables (E.g. Vapes; flower) Fast acting; Easy to use; Social; Familiar Non-discreet; Smoking/Vaping are illegal in many public settings; Can feel harsh on the lungs Instant 45 minutes-1 hour Are trying to quit cigarettes or need fast-acting relief
Topicals (E.g. Lotions; balms; gels) Can be applied directly to affected area; Bypasses liver metabolism; Long-lasting; Can be worked into daily hygiene routine Slow to take effect Varies widely due to factors like hair growth and amount of fatty tissue Typically 5+ hours Experiencing local pain of the skin or joints or into body care in general.
Transdermal Patches Longest lasting effects;Bypasses liver metabolism;Steady release of CBD into the bloodstream May take hours to feel effects Varies depending on amount of fatty tissue and hair on the skin 1-2 days Have chronic pain or will go a long period of time where the other delivery methods aren't available

Choose a CBD Brand with a Dosage You Can Trust

Figuring out how much CBD oil to take can feel like trying to navigate through a complicated maze. The sheer volume of CBD brands on the market can create confusion for consumers, and when you take a closer look, it’s not difficult to understand why. Not only do vendors use different source materials (CBD-rich cannabis vs. industrial hemp, different strains, etc.), but they also implement different extraction techniques .

Adding to the confusion, many vendors recommend excessive doses, while others suggest amounts that are a fraction of what experts would consider effective.

As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.

While perhaps not as ideal as a CBD dosage chart, we at CBD Oil Review (COR) have created an official COR Serving Standard through an extensive analysis of hundreds of products.

The (COR) Serving Standard is 25mg of CBD, taken twice daily.

Additionally, our analysis suggests  increasing the amount of CBD you take every 3-4 weeks by 25mg until you attain symptom relief (inversely, decrease by 25mg if symptoms worsen).

Consider Why Your Health Would Benefit from CBD

Cannabinoids such as CBD have a dizzying array of functions in the human body, influencing  everything from inflammation to anxiety and depression. You don’t necessarily need to have a serious illness to benefit from CBD; even healthy individuals can experience a remarkable increase in their quality of life with its use.

The following is a chart of illnesses/conditions that whose symptoms may be relieved by CBD:

Keep in mind that this CBD benefits list is in no way complete; we are only beginning to discover how cannabinoids can help.

Know You Cannot Overdose on CBD

There is no established lethal dose of CBD, and chronic use/high doses of up to 1500 mg per day (30x  MORE than the COR Serving Standard!) have been repeatedly shown to be well tolerated by humans.

As with any natural product, it is important to speak with your physician prior to beginning use. There are some slight risks associated with using CBD in high doses or for extended periods of time, including:

  • Mild Low Blood Pressure
  • Dry Mouth
  • Lightheadedness
  • Sedation
  • Reduced activity of T and B Cells
  • Decreased Fertilization Capacity
  • Reduced p-Glycoprotein activity
  • Reduced activity of Cytochrome P450 (CYP450) Enzyme

Keep in mind that these side effects illustrate worst-case scenarios with CBD, and are not necessarily typical.

There is one major exception to the “generally harmless” attitude about CBD and that is the negative effect cannabinoids can have on the functioning of the liver’s CYP450 enzyme. Approximately 60% of all pharmaceutical drugs are degraded by this enzyme, and CBD can slow the metabolization of these drugs:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV-antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

Before you start taking CBD, please read about drug interactions.

It is important to note that even something as benign as grapefruit juice can cause the same CYP450 enzyme inhibitory action as CBD.

The most important things to do before taking CBD (or any other herbal product) are research any possible drug interactions and talk with your physician to address any additional questions regarding CBD drug interactions or overdose concerns. You and your doctor together will always know best!  

Understand How Your Genetics Impact CBD Dosing

As if you didn’t have enough factors to consider when deciding your ideal CBD oil dosage, now you have to think about how your own genetics can impact this amount.  

Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system, which is an important variable when figuring out how to use CBD oil.

How lifestyle choices impact the effect of CBD

Various substances can profoundly affect CB1 receptors. Certain lifestyle choices can impact how your body metabolizes CBD.

We are only beginning to understand which factors influence CBD metabolism, and as such it’s a good idea to take anything related to this emerging science with a grain of salt. As with any natural substance, consult with your physician about any questions and/or concerns you may have regarding CBD and how to use CBD oil.

Rest Easy Knowing CBD Oil Is Not Physically Addictive

People often ask us, “Can I get addicted to CBD oil?” This is a tricky question, and the answer ultimately depends on your school of thought.

Based strictly on chemistry, the answer is no. Cannabidiol is not physically addictive in the same way substances like heroin, cocaine, alcohol, opiates, benzodiazepines, and related substances can be. Further, CBD cannot produce any physical withdrawal symptoms in and of itself upon cessation of use.

(Interestingly, CBD is currently undergoing study for its ability to minimize withdrawal from drugs with severe cessation symptoms, like opiates.)

However, human beings can get addicted to just about anything that isn’t chemically addicting: exercise, music, sex, and food are great examples.

Those who take CBD daily to relieve symptoms of chronic illness and other severe conditions may find that their unpleasant sensations return shortly after they miss a dose. This is no different than one’s headache returning once the effects of ibuprofen wear off.

However, because CBD can alter the levels of essential liver enzymes, it is crucial to do your research, talk to your physician, and figure out the best way to take CBD oil for your specific situation. Information and education will be your allies in your quest for healing.

Get the Most Bang for Your Buck

If you’ve been using CBD products for some time without verifying the potency through their vendors, it’s highly probable you’ve been using a minimally effective formulation that hasn’t been delivering as much CBD as you thought (or as much as you’ve paid for!).

This is why CBD Oil Review exists, why we’ve created our five-badge rating system, and why we’ve enlisted independent reviewers to verify that CBD companies are being ethical.

Becoming a CBD Oil Review member not only supports our mission, but members also get new deals on five-star brands only, delivered directly to their inbox. If you are looking for which brands to trust or which products to purchase, take a look at our buyers guides here:

  1. Top 10 Best Products to Buy
  2. Best CBD Products for Pain
  3. Best CBD Vape Cartridge

Consider a Cannabis Doctor to Answer Your Difficult Questions

Most doctors don’t specialize medicinal cannabis and CBD oil. This means they may not be able to help you as thoroughly as you had hoped and they may be unable to offer guidance when it comes to helping you decide how much CBD oil to take. It is also worth noting that many patients feel uncomfortable talking to their doctor about cannabis and CBD.

If you have detailed questions about how much CBD oil to take, how to take CBD oil, drug interactions, or just want to know what to do next, consult with a cannabis doctor today!

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280 responses to “CBD Oil Dosage: General Tips to Assess How Much CBD to Take”

  1. Avatar North Dakota CBD says:

    Extremely interesting.

  2. Avatar Jonathan Hansen says:

    It’s interesting that you mention that CBD oil can help you if you suffer from anxiety. I have been very anxious lately due to my college exams, so I’m thinking about buying a CBD tincture that I can take. I’m going to search for a reputable business that can sell me a CBD tincture.

  3. Avatar Alabama CBD says:

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  4. Avatar huston says:

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  5. Avatar Xavier says:

    How in the world can you quote all those doses in the studies without verifying whether they were effective? Almost none of those studies found positive effects of those doses of CBD on the disorders.

  6. Avatar Greg Hampton says:

    I like what you said about using liquid CBD since it’ll have a suggested serving size. My sister wants to relax more in the coming weeks. I’ll share this information with her so that she can look into her options for professionals who can help her with this.

  7. Avatar Mary R. Cruz says:

    Thanks for sharing the information about CBD oil… I’ll keep in mind these benefits and side effects … This blog really helpful for me.

  8. Avatar James D. Watkins says:

    your blog is very informative. thanks for posting.

  9. Avatar Raiman.A says:

    Finding the best dose to take is an individualized process. Dosage will depend on a myriad of factors including why you’re taking it, your personal physiology, endocannabinoid system, and sensitivity.

  10. Avatar Todd Berenson says:

    I use 6000 mg cannaexspesso . half a dropper per day is 50 mg x 2 100 mg a day. Any dose under 100 mg daily has done zero for my chronic pain,diabetes,sleep disorder and anxiety.most 30ml bottles are less than 500mg. 30 droppers per 30ml is standard as each dropper is. 1ml. My bottle has a .05ml dropper and I get 60 droppers per bottle at 100 mg per dropper.nothing worked till I found this 6000 mg brand that lasts 2 month.

  11. Avatar Rebecca Gardner says:

    I was surprised when you said that the effects of CBD can help people dealing with things as different as inflammation and depression. I opened up to one of my close friends about my depression yesterday, and she recommended that I try CBD oil to counteract some of the effects. Reading your article made me feel al lot more comfortable with the idea of trying CBD, so thanks for taking the time to share!

  12. Avatar Todd F. Pedersen says:

    The tips given are helpful and noticeable……

  13. Avatar Vivian Black says:

    You made a great point about learning the types of products and how oil can be chosen depending on your route of administration. My husband and I are looking for a full-spectrum CBD oil that we can buy for his arthritis. We will keep these tips in mind as we search for a professional that can help us best.

  14. Avatar Kim says:

    That really is amazing since I’ve known so many with ALS that tried many things but lost the fight with ALS. May God continue to bless you everyday with this awesome gift??

  15. Avatar Sebastian Rahaus says:

    I am grateful for the post. Really looking forward to reading more. I will read on!!

  16. Avatar Darby Venture says:

    This blog about CBD Dosage – How Much CBD Oil Should I Take?
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  17. Avatar Happy Tea says:

    CBD really works! I’ve being using the BioCBDplus Total Body Care and can say that it has definitely improved my sleep quality, helped significantly with my anxiety and helped with pain.

  18. Avatar Happy Tea says:

    It’s true, There is no sure cure, solution, or remedy. But, pain victims can find relief in several therapies.

  19. Avatar Amy Anderson says:

    There has been thousands of studies showing that it works. this will hurt BIGPHARMA companies. They want our money they dont care about our lives. crippled with chronic pain and suffered terribly. Nothing worked until i came across CBD. Who agrees with me that CBD oils are safe and really help, I am a living example. It can be used not only for medicinal purposes, but also as prophylactic. But do not forget that you need to always choose for yourself the correct dosage, how to do it correctly.

  20. Avatar Shaylee Packer says:

    You mention that there are countless variables that goes into how much CBD oil one should take. My sister is just wanting to start taking the oil for migraine relief. I will have to pass this information on to her. You also mention that it is a good idea to keep a journal of how much you took, and the way you felt afterwards. That seems like a good idea in figuring out your specific dosage.

  21. Avatar Dena says:

    I was just diagnosed with this same condition and do not want to take the prescribed medication, I was looking for information on CBD and dosage. Thank you!!

  22. Avatar Debbie says:

    I know that’s hard to understand. I have spent well over a thousand dollars buying medical marijuana and not having it work consistently (the last purchase was for a cbd tincture and a part cbd/part thc tincture and neither helped-not even a little, so I wasted $120. I find a strain that helps but since there are thousands of strains I often can’t get the same strain even going to multiple dispensaries. My doctor wanted to help, so he wrote me a prescription for synthetic thc to help w/ my appetite. I have a prescription plan that covers it, so right now that is what I am doing until I can find something better.

  23. Avatar James says:

    Research and make sure the enzyme blocked does not react with chemo therapy as a lot of chemo drugs are effected by it. May actually reduce the effect of the medication or in some other cases make the chemo medication remain much higher concentrations than can be handled. Similar to how grapefruit effects many medications.

  24. Avatar Daisy says:

    Hi Sandala. So sorrybto hear that. Where fid you get thecrick simpson oil? I would likecto get some for my husband but im afraid of getting one thats not legitimate. And i dont know dosage. Please send me an email with more info. Thank you so much. [email protected].

  25. Avatar Tori Raddison says:

    I didn’t know that doctors can’t prescribe cannabinoids but I guess it makes sense if there’s no recommended dose they can suggest. I can see why finding the right dosage is so important. I think it’s smart to start with too little than too much.

  26. Avatar shantelfullerton says:

    Did you already try WeedBorn CBD products?

  27. Avatar timothy shelton says:

    I suffer from high anxiety and do not get much sleep. So I decided to try this so call CBD oil. After about a month of taking about 50 mg a day I noticed I was more relaxed, and less stressed out. I also sleep the whole night, out cold and wake up feeling totally refreshed. I have suffered so many years and I am so glad that I found something that really helps me. I dont know about any one else but I love it. Go CBD!!!

  28. Avatar Sam Hurr says:

    It is up to the prescription which doctor suggests you after looking to you and your disease moreover to take the prescription you need to consult your family doctor which might say dosage of Cbd gummies.

  29. Avatar Sebastian Rahaus says:

    I really appreciate your efforts put in this blog post. Keep it up!!

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